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#4 (permalink) |
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Admin
Join Date: Dec 2001
Location: Gorham Me
Posts: 243
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George has been busy in his personal life. He is still around but not as often as he would like.
I have taken over the site for him... including hosting and all of the associated costs and administration to keep the site running. My goal was revamp the site and bring it back to its former glory of a few years ago. Unfortunately, my time has been limited due to work. I am hoping for a slight slowdown there so that I may spend more time on PcTechTalk.com If you have any suggestions or wish to help with that task, please drop me a PM. George founded the site and put a ton of time and effort into it over the years... he must do what is best for himself and his family. We all wish him the best! .... I'm sure he will be back around when time permits. -JRW |
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#6 (permalink) |
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Registered User
Join Date: Dec 2008
Posts: 14
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谷氨酸用途 1. 下游产品开发将有一定反应活性的双功能基试剂氯乙醇和L—谷氨酸直接酯化保护羧基,用三光气活化成其相应的N—羧酸酐,可直接得到侧链具有一定反应活性的聚L—氯乙基谷氨 酸酯。谷氨酸的结构中有一个氨基和两个羧基,在光气的作用下,羧基和氨基会形成环状N—羧酸酐,由于羧基也较为活泼,可 能会参与成环反应,因此在成环反应之前,通常用苄醇将羧基进行保护,这样得到的聚合物的侧链活性极低,一般 需经进一步氢化脱苄或胺解脱苄,才能得到有反应活性的侧链,我们选用双功能基试剂氯乙醇作保护基因,在聚合 之后可直接得到有反应活性的侧链,可有效地简化合成路线。侧链酯化过程是一个可逆反应,随着体系内水含量的 不断增加,反应速度会降低,导致产率不高。在形成谷氨酸苄酯时,采用分子筛脱水,操作大大简化。新型的聚合氨基酸,含有氨基的药物或靶向基因,可以方便的接入聚谷 氨酸的分子中,形成大分子前药或靶向大分子载体,接入特异性的基因,可进行特殊的分离或提纯,这一聚合物在 医药领域会有很广泛的应用前景。谷氨酸可生产许多重要下游产品如L—谷氨酸钠、L—苏氨酸、聚谷氨酸等。
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#7 (permalink) |
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Registered User
Join Date: Nov 2008
Posts: 40
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#8 (permalink) |
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Registered User
Join Date: Jan 2009
Posts: 17
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